Could the Black Death happen again?

No.

Bubonic plague killed at least one-third of the population of Europe between 1346 and 1353. But that was before we knew it was caused by the bacterium Yersina pestis.

Bubonic plague does still occasionally occur in small flare-ups of a few dozen cases, but we have antibiotics to treat it now. Plus, better hygiene makes it very hard for a disease spread by flea bites to become a global pandemic again.

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