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RECOVERY trial: 2,000 patients to receive coronavirus antibody therapy © Getty Images

Coronavirus: 2,000 patients to receive antibody therapy

Published: 15th September, 2020 at 10:13
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The antibody treatment, REGN-COV2, is part of the RECOVERY trial run by the University of Oxford.

An antibody treatment that could lessen the impact of COVID-19 is to be trialled on patients in UK hospitals.


The RECOVERY trial, co-ordinated by the University of Oxford, will assess the impact of giving patients the treatment, REGN-COV2, alongside usual standard care to see if it lessens the severity of COVID-19 and can reduce deaths.

In June, the RECOVERY trial, which includes 176 UK hospital sites, found that a cheap steroid called dexamethasone could save the lives of people with severe infection.

In the new phase 3 study, at least 2,000 coronavirus patients will be randomly allocated to receive REGN-COV2 plus usual care, and the results will be compared with at least 2,000 patients not on the therapy.

Read more about the RECOVERY trial:

REGN-COV2, which was created by the US firm Regeneron, is made up of two monoclonal antibodies (REGN10933 and REGN10987). These are man-made antibodies that act like human antibodies in the immune system. The cocktail of drugs targets two components in the spike protein of the COVID-19 virus with the aim of interrupting its ability to infect.

Peter Horby, professor of emerging infectious diseases and global health at the University of Oxford and chief investigator of the trial, said: “We have already discovered that one treatment, dexamethasone, benefits COVID-19 patients, but the death rate remains too high so we must keep searching for others.

“The RECOVERY trial was specifically designed so that when promising investigational drugs such as REGN-COV2 became available they can be tested quickly. We are looking forward to seeing whether REGN-COV2 is safe and effective in the context of a large-scale randomised clinical trial.

"This is the only way to be certain about whether it works as a treatment for COVID-19.”

Today’s news is another promising step in the search to find effective treatments
Prof Jonathan Van-Tam

Nick Cammack, who is leading COVID-19 therapeutics work for Wellcome, said: “Novel antivirals and monoclonal antibodies are among the most exciting and promising treatments for COVID-19 because they are specific to the disease, but they are also traditionally the most expensive.

“Large-scale randomised controlled studies like RECOVERY give us the best understanding of whether drugs like REGN-COV2 are safe and effective against COVID-19, but we must ensure that any successful treatment is available to everyone who needs it globally.”

England’s deputy chief medical officer, Professor Jonathan Van-Tam, said: “Today’s news is another promising step in the search to find effective treatments, which will improve our ability to deal with this destructive virus, and a testament to the confidence that others around the world have in this brilliantly conceived and executed trial.

“I look forward to seeing how REGN-COV2 performs in clinical trials, and I urge people to volunteer in this research which could ultimately save many lives.”

Read the latest coronavirus news:

Professor Fiona Watt, executive chairwoman of the Medical Research Council, said: “Monoclonal, or targeted, antibodies are already used to treat cancer and autoimmune diseases. The new trial will tell us whether antibodies that attack the virus can be an effective treatment for COVID-19.”

Regeneron has linked up with the pharmaceutical giant Roche to increase the global supply of REGN-COV2 if it proves effective. The firm said that studies in animals have shown the cocktail can reduce the amount of virus and damage to the lungs.


Martin Landray, professor of medicine and epidemiology at the University of Oxford, said: “Up to now, we have largely been studying whether existing drugs can be repurposed to tackle this new disease, but we now have the opportunity to rigorously assess the impact of a drug specifically designed to target this coronavirus.”


Sara RigbyOnline staff writer, BBC Science Focus

Sara is the online staff writer at BBC Science Focus. She has an MPhys in mathematical physics and loves all things space, dinosaurs and dogs.


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