COVID-19: Public immunity “waning quite rapidly” as less than 5 per cent have antibodies

COVID-19: Public immunity “waning quite rapidly” as fewer than 5 per cent have antibodies

A study of 365,104 adults in England shows that antibody levels have fallen, with the largest drop in people aged 75 and over.

Scientists have found that coronavirus immunity could only last a few months after a study revealed a decline in protective antibodies.

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Research by Imperial College London estimated just 4.4 per cent of adults had some form of immunity against COVID-19 in September, when cases began to increase again. This is compared with 6 per cent found to have antibodies between 20 June and 13 July, and 4.8 per cent between 31 July and 31 August.

Experts said the data from the Real-Time Assessment of Community Transmission (REACT-2) study – which has been released in a pre-print paper that has not been peer-reviewed – showed immunity was “waning quite rapidly”, which could lead to an increased risk of reinfection.

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Some 365,104 adults took part in three rounds of testing for the study between late June and September to measure the prevalence of coronavirus antibodies in England.

The study found that antibody levels fell by 26.5 per cent overall during the three-month period.

Those aged 18-24 had the highest prevalence of antibodies and lowest decline in antibody levels at 14.9 per cent. Meanwhile, people aged 75 and over had the lowest prevalence and saw the largest drop, with antibody levels falling by 39 per cent.

Daily confirmed COVID-19 cases in the UK © PA Graphics
Daily confirmed COVID-19 cases in the UK © PA Graphics

It remains unclear what level of immunity antibodies provide, or for how long this immunity lasts, scientists said.

“The big picture here is that after the first wave (of coronavirus), the great majority of the country still did not have evidence of protective immunity,” said Graham Cooke, professor of infectious diseases at Imperial College London.

“So although we are seeing a decline in the proportion of people who are testing positive, we still have a great majority of people who are unlikely to have been exposed.

“So the need for a vaccine is still very large if you want to try and get a large level of protection in the population.”

We are a long, long way from any idea that the population will be protected by other people
Helen Ward, Imperial College London

The study found there was no change in antibody positivity in healthcare workers between June and September.

Helen Ward, professor of Public Health at Imperial College London, said this could indicate “ongoing transmission” of coronavirus in those settings or “repeated exposure”.

“Even at best, (in the first round of the study) 94 per cent of the population remained not likely protected,” said Prof Ward when asked about herd immunity. “Now that has declined to over 95 per cent of the population who don’t have evidence of antibodies.”

“So I think we are a long, long way from any idea that the population will be protected by other people.” She added that immunity in England was “waning quite rapidly”.

In the latest round of the study, between 15-28 September, the prevalence of antibodies remained highest in London, and in those of black and Asian ethnicity.

The decline in people testing positive for antibodies was largest in those who did not report having had COVID-19, compared to those who said they previously tested positive for the virus.

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“Our study shows that over time there is reduction in the proportion of people testing positive for antibodies against the virus that causes COVID-19,” said Professor Paul Elliott, director of the REACT programme at Imperial, from the School of Public Health.

“It remains unclear what level of immunity antibodies provide, or for how long this immunity lasts.

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“If someone tests positive for antibodies, they still need to follow national guidelines including social distancing measures, getting a swab test if they have symptoms and wearing face coverings where required.”