That largely depends on the VR device being used and the size of your glasses. My relatively small frames fit comfortably inside most devices I have tried, like the simple I AM CARDBOARD viewer and VR-One headset. More advanced headsets give you some control over focus, in which case you may well find you don’t need glasses at all as you can adjust the lenses to compensate. Other headsets, like Oculus Rift, come with several different lenses that the user can switch around to provide the best results. The only way to be sure is to try the device before buying.