Pretty much everything we do, everything we are, is based on the connections between cells, the synapses, that form in our brain. Indeed, for a long time it was assumed that the adult brain was essentially ‘fixed’, and couldn’t be changed in any significant way.


Modern evidence means this assumption is no longer so dominant, and the adult brain is acknowledged as being more flexible, more changeable, than was originally assumed. Even so, the idea of our brains actively consuming itself, essentially eating different parts, is a strange one. Nonetheless, that’s exactly what’s happening, all the time.

Phagocytosis is a process whereby cells will envelop and consume smaller cells or molecules, in order to remove them from the system. It’s basically cells eating other cells, or substances. Our immune system is based on this; dedicated white blood cells consume pathogens, thus getting rid of them and their disruptive influence on our bodies.

A lot of phagocytosis is happening in the brain, at any given time. While keeping pathogens and other invaders out is obviously very important, phagocytosis is happening just to keep the brain running as is, i.e., maintaining homeostasis.

More like this

It’s important to remember that the brain is an incredibly busy and demanding organ. Estimates suggest it uses up about a third of the body’s ready energy supply, just by staying alive and doing what it needs to do. This means that the brain is something of a cellular powerhouse; there are countless complex processes happening between and within our brain cells, all the time.

The thing is, all these processes will have unusable byproducts. The brain’s workings create a lot of debris. And this debris has to be got rid of, because otherwise it builds up and disrupts things, just like how no litter collection for months would make residential streets very hard to get around. A lot of this clearing away of cellular detritus happens when we sleep (that’s one theory as to why we sleep at all), and processes involving phagocytosis are how it’s cleared.

But it’s not just everyday housekeeping. A lot of the time, the connections in the brain need to be removed or changed. When we hit adolescence, a process called ‘pruning’ is initiated, whereby all the unused neurological connections we accumulate during childhood are got rid of, and the resources they were hogging unhelpfully are redirected to more useful things, making the brain more efficient and ready for adult life. And all this happens because the brain is, in a very real sense, eating itself. But in ways that make it better, not worse.

Our brains aren’t static. They’re flexible, adaptable, constantly reacting to what life throws at them. That’s largely the source of their power. But they wouldn’t be able to do this if they weren’t willing to eat parts of themselves on a regular basis.

Read more:



Dean is a neuroscientist, author, blogger, occasional comedian and all-round ‘science guy’. He is the author of the the popular Guardian Science blog ‘Brain Flapping’ (now ‘Brain Yapping’ on the Cosmic Shambles Network with accompanying podcast), the bestselling books The Idiot Brain and The Happy Brain, and his first book aimed at teens, Why Your Parents Are Driving You Up the Wall and What To Do About It.