Everything you need to know about B.1.617.2, the “Indian variant” of coronavirus © Jane Barlow/PA

Everything you need to know about B.1.617.2, the “Indian variant” of coronavirus

It is expected that the variant will become the dominant strain in the UK.

Further cases of B.1.617.2, the “Indian variant” of coronavirus have been identified in the UK, with 86 local authorities now reporting five or more confirmed cases, ministers have said.

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Health Secretary Matt Hancock told the House of Commons on Monday 17 May that while the B.1.617.2 variant seemed more transmissible, the evidence suggested coronavirus vaccines were effective against it.

Hancock said the variant had become the dominant strain in parts of the North West of England.

A range of measures are being taken to tackle its spread, including accelerating second doses of vaccines for people over 50 and the clinically vulnerable, he added.

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How many cases of the B.1.617.2 variant have been detected in the UK?

Hancock told the Commons on 17 May there were now 2,323 confirmed cases of B1617.2 in the UK – of which 483 were in Bolton and Blackburn with Darwen, where it is now the dominant strain. He said cases there had doubled in the last week and were rising in all age groups.

Hancock also told MPs there were 86 local authorities where there are five or more confirmed cases, with Bedford the “next biggest cause of concern”.

As of 12 May, there were 1,313 confirmed cases of the B.1.617.2 variant in the UK.

Is this surge leading to more hospital admissions and deaths?

Hancock said that in Blackburn, hospital admissions were “stable”, with eight people currently in hospital with COVID.

In Bolton, 19 people were in hospital with coronavirus – the majority of whom were eligible for a vaccine but had not received one, he added.

Blackburn with Darwen’s director of public health Professor Dominic Harrison has said rising cases are unlikely to lead to increased deaths and hospital admissions, but that the situation will be monitored daily.

Is the B.1.617.2 variant more transmissible?

Informing MPs of the latest scientific assessment on the Indian variant, the Health Secretary said early evidence suggested the variant was more transmissible than the Kent variant.

He added that it was not yet known how much more transmissible it was.

The Scientific Advisory Group for emergencies (SAGE) has said there is a “realistic possibility” that the Indian coronavirus variant could be as much as “50 per cent more transmissible” than the Kent strain.

But, at present, there is no evidence the B1617.2 variant is resistant to current vaccines.

Hancock said that early laboratory data from Oxford University corroborated the evidence from Bolton Hospital and the initial observational data from India that vaccines are effective against this variant. He added that whilst this is “reassuring”, the higher transmission rate “poses a real risk”.

What is being done?

Hancock said the Government had “surged in” its rapid response team to Bolton and Blackburn, with a team of 100 people visiting around 35,000 people to distribute and collect tests.

He also said six new testing units had been installed, 50 new vaccinators brought in and two new vaccination centres opened as well as extending the opening hours and capacity of existing sites.

Over the weekend, the rate of vaccination in Bolton quadrupled, with 6,200 people getting the jab.

Hancock also confirmed surge testing will take place in Bedford after a rise in Indian variant cases of coronavirus.

Johnson told a Downing Street press conference on 14 May that second doses – which give people maximum protection against COVID-19 – will also be brought forward from the planned 12-week interval to eight weeks.

First doses are also being prioritised for anyone eligible who has not yet come forward including the over-40s.

Prof Chris Whitty said local “surge vaccinations”, which would make first doses more widely available by offering them to all over-18s, was not being pursued because there is a “finite” supply of doses and that younger people were at less risk from the virus.

Hancock said that people taking up their offer of a vaccine “will help us all get out of this pandemic” and announced that people aged 37 will be offered the vaccine from Tuesday.

He added: “The approach is to make sure we get as many second vaccinations done as possible, as many first vaccinations amongst the vulnerable groups, and then as many vaccinations as possible for those eligible groups who are under the age of 50.”

Will bringing forward second jabs help tackle the rise?

When the national vaccine programme began in the UK, officials took the bold decision to delay administering booster shots so that elderly and vulnerable people could more quickly receive their first shots.

Studies have since shown that giving the second dose 12 weeks after the first, instead of 21 days, can produce a stronger immune response.

Thus it remains to be seen whether bringing forward the date of the second dose will help curb rising infections.

Is the B.1.617.2 variant driving the second wave in India?

On Thursday 13 May, India recorded 4,000 deaths and 343,144 new COVID-19 infections over the last 24 hours.

Scientists believe B.1.617.2 may be more transmissible than the UK variant (B.1.1.7), which was first detected in Kent last year, and may be linked to the second wave in the country.

Professor Robert Dingwall, who is a member of Nervtag (New and Emerging Respiratory Virus Threats Advisory Group) – an expert committee which advises the Government on the threat posed by new respiratory viruses, said that while B.1.617.2 may be capable of becoming the dominant variant in the UK, the risk of a surge in deaths or hospital admissions remains low.

Will vaccines still work against the B.1.617.2 variant?

At present, there is no evidence the B.1.617.2 variant is resistant to current vaccines. In fact, early lab data suggests that the vaccines are effective against it.

Although deemed to be more transmissible, it does not feature the E484K mutation found in the South African variant of the virus, which could help the virus evade a person’s immune system and may affect how well coronavirus vaccines work.

“This variant seems to be better managed by the vaccines than the South African variant so that vaccinated people have only a very low risk of infection that is likely to be mild,” said Dingwall.

What other variants of concern have been identified in the UK?

All viruses undergo small genetic changes as they make copies of themselves in the host. Most of these mutations are harmless but some can make the disease more infectious or threatening, and evade protection gained through infection or vaccination.

PHE has designated the UK, India, South Africa and Brazil (P.1) variants as being “of concern”.

Current vaccines have been designed for earlier versions of coronavirus, but scientists believe they should still work, but may be less effective. But experts are confident existing vaccines can be tweaked to better tackle emerging mutations.

The UK Government has a deal with biopharmaceutical company CureVac to develop vaccines against future variants, and has pre-ordered 50 million doses.

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